Protein secretion is an old problem of fundamental interest and while a number of question remain unsolved, we have focused on the following key questions.
1. Mechanism of collagen secretion to address the issue of tissue fibrosis (collagenopathies).
2. Mechanism of Mucin secretion and the associated pathologies of COPD and cystic fibrosis
3. The mechanism of unconventional protein secretion
4. The shape and the biogenesis of functional Golgi cisternae
5. The biogenesis of transport carriers at the Golgi cisternae