Wolfgang Löscher has held posts in academical institutions and pharmaceutical industry. His research interests are in the pharmacology of the brain, including the pharmacology of antiepileptic drugs, the mechanisms of pharmacoresistant epilepsy, and the pathophysiology of temporal lobe epilepsy with the aim to find new targets for treatment.

His many cooperations with pharmaceutical industry have fostered the development of new antiepileptic drugs such as levetiracetam. In addition, his research efforts have included the investigation of tolerance and dependence of psychoactive drugs, the pharmacology and pathophysiology of rodent models of movement disorders such as dystonia, as well as evaluation and characterization of toxic effects of electromagnetic fields.

He has over 400 refereed publications and is listed in the 2008 ISI web-list of the world’s most cited authors.