Wenqian He

基本信息

Career Trajectory

Bio

Program lead for the development of a bispecific-antibody therapy for treating cancer Lead a cross-functional team of 20+ scientists in protein engineering, pharmacology, toxicology, bioinformatics, and translational research Design and develop in vitro assays/animal models to evaluate immune responses mediated by drug candidates

Research Interests

Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts

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Abstract LB349: the Use of PBMC Humanized Mice to Test the Efficacy and Safety of Antibody and Cell-Based Cancer Immunotherapeutics

Destanie Rose,Won Lee,Guoxiang Yang,Jiwon Yang,Mingshan Cheng,Wenqian He,Bernard Buetow,Allison Vitsky,Maggie Liu,Bart Jessen,James Keck

CANCER RESEARCHno. 8 (2023)

Cited0Views0Bibtex

1258 PBMC Humanized Mouse Model with Clinical Relevance in Assessing the Safety Profile of 4–1BB Agonists Utomilumab and Urelumab

Destanie Rose,Wenqian He,Bernard Buetow,Allison Vitsky, Maggie Lui,Jiwon Yang,Guoxiang Yang,James Keck,Bart Jessen

Regular and Young Investigator Award Abstracts (2022)

Cited0Views0Bibtex

Validation of a Clinically Relevant Humanized Mouse Model for the Safety Assessment of 4-1BB Agonists Utomilumab and Urelumab

James G. Keck,Wenqian He,Bernard S. Buetow,Allison Vitsky,Maggie Liu,Jiwon Yang,Guoxiang Yang,Danying Cai,Bart Jessen

JOURNAL OF CLINICAL ONCOLOGY（2022）

Cited1Views0Bibtex

CD40 Agonist-Induced IL-12p40 Potentiates Hepatotoxicity

Caroline Bonnans,Graham Thomas,Wenqian He, Breanna Jung,Wei Chen, Min Liao,Jonathan Heyen,Bernard Buetow,Smitha Pillai, Diane Matsumoto,Javier Chaparro-Riggers,Shahram Salek-Ardakani,Yan Qu

Journal for ImmunoTherapy of Cancer（2020）

Cited13Views0WOSBibtex

Baseline Frequency of Inflammatory Cxcl9-Expressing Tumor-Associated Macrophages Predicts Response to Avelumab Treatment (vol 32, pg 107873, 2020)

Yan Qu,Ji Wen,Graham Thomas,Wenjing Yang,Weiwei Prior,Wenqian He,Purnima Sundar, Xiao Wang,Shobha Potluri,Shahram Salek-Ardakani

CELL REPORTS（2020）

Cited48Views0Bibtex

Baseline Frequency of Inflammatory Cxcl9-Expressing Tumor-Associated Macrophages Predicts Response to Avelumab Treatment

Yan Qu,Ji Wen,Graham Thomas,Wenjing Yang,Weiwei Prior,Wenqian He,Purnima Sundar, Xiao Wang,Shobha Potluri,Shahram Salek-Ardakani

Cell Reports（2020）

Cited63Views0WOSBibtex

Alveolar Macrophages Are Critical for Broadly-Reactive Antibody-Mediated Protection Against Influenza A Virus in Mice

Wenqian He,Chi-Jene Chen,Caitlin E. Mullarkey,Jennifer R. Hamilton,Christine K. Wong,Paul E. Leon,Melissa B. Uccellini,Veronika Chromikova,Carole Henry,Kevin W. Hoffman,Jean K. Lim,Patrick C. Wilson,Matthew S. Miller,Florian Krammer,Peter Palese,Gene S. Tan

Nature Communications（2017）

Cited134Views0WOSNATUREBibtex

134

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Paul E. Leon,Teddy John Wohlbold,Wenqian He,Mark J. Bailey,Carole J. Henry,Patrick C. Wilson,Florian Krammer,Gene S. Tan

Journal of Visualized Experiments（2017）

Cited10Views0WOSBibtex

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively Via MyD88 to Induce Protective Antiviral Immunity in Mice

Peter H. Goff,Tomoko Hayashi,Wenqian He,Shiyin Yao,Howard B. Cottam,Gene S. Tan,Brian Crain,Florian Krammer,Karen Messer,Minya Pu,Dennis A. Carson,Peter Palese,Maripat Corr

Journal of Virology（2017）

Cited33Views0WOSBibtex

Epitope Specificity Plays a Critical Role in Regulating Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza A Virus

Wenqian He,Gene S. Tan,Caitlin E. Mullarkey, Amanda J. Lee,Mannie Man Wai Lam,Florian Krammer,Carole Henry,Patrick C. Wilson,Ali A. Ashkar,Peter Palese,Matthew S. Miller

Proceedings of the National Academy of Sciences（2016）

Cited177Views0WOSBibtex

177

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Principal Scientist

Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts