Research Interests
Vascular immunology and atherosclerosis. Dr. Yang’s laboratory uses microarray transcriptome, next generation DNA sequencing including RNA-Seq, T cell epitope mapping, SEREX and other biochemical, immunological approaches and transgene/gene knock-out disease models in order to determine cardiovascular disease (CVD) risk factors, such as hyperlipidemia-, hyperglycemia-, uremia-, endotoxemia, impact the development/progression of vascular inflammation and atherosclerosis.

Immunometabolism. Dr. Yang’s laboratory also aims to study how biochemical metabolites in CVD-related pathologies act as either danger signals or homeostatic signals to regulate antigen processing/presentation, vascular immune responses and atherosclerosis.

Epigenetic pathology. Dr. Yang’s laboratory also studies how CVD risk factors regulate histone modification process and gene expressions in vascular inflammation and atherosclerosis.