I,Yashpal Singh Chhonker currently works at the Dept. of Pharmacy Practice, UNMC. My laboratory work on the understanding of pharmacokinetics (PK) of NCE’s in relationship to its underlying biologic mechanisms. By evaluating the PK properties of NCE’s we tend to determines the onset, duration, and intensity of a therapeutic agent. We carry out regulatory and clinical PK studies. Our lab is also involved in development of bioanalytical method using HPLC and LC-MS/MS platform for estimation of NCE’s, drugs, metabolites, peptides in biological matrices as per US-FDA, ICH etc Mathematical modelling of PK and PK-PD data are carried out. These mathematical model are used for simulation of drug concentration profile prior to in-vivo studies and help in optimization of dose and dosage regimen.