As a statistical geneticist, Dr. Li’s research interest is primarily in statistical method development and its application for genetic research of human complex diseases. She has worked extensively in the following disease areas: Alzheimer disease (AD), Myopia, Fuchs endothelial corneal dystrophy (FECD), drug induced liver injury (DILI), osteoarthritis (OA), and various postoperative outcomes of cardiac surgical patients. For statistical method development, Dr. Li is active in the development of various allelic or gene-base association tests for quantitative traits, censored trait, and zero-inflated outcomes for common, rare, or x-linked variants. Dr. Li’s group continues working on cutting edge statistical methods that can be applied to current genetic and genomic data.