Yoon Sim Yap

Associate Professor

Duke-NUS Medical School National University of Singapore;Yong Loo Lin School of Medicine, National University of Singapore;Division of Medical Oncology, National Cancer Centre Singapore

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Career Trajectory

Bio

A recipient of the Singapore National Medical Research Council (NMRC) Clinician Scientist Award (CSA), her research focuses primarily on clinical and translational research in breast cancer, including liquid biopsies and predictive biomarkers, development of novel therapeutic strategies, and epidemiologic studies on treatment outcomes in breast cancer. She is the principal investigator of several phase 1 to 3 clinical trials for various compounds, including CDK inhibitors, PI3K and mTOR inhibitors, selective estrogen receptor degraders, HER2-targeting agents and immunotherapy, in addition to investigator-initiated studies.

Research Interests

Papers共 263 篇Author StatisticsCo-AuthorSimilar Experts

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A Deep-Learning Model for Quantifying Circulating Tumour DNA from the Density Distribution of DNA-fragment Lengths

Guanhua Zhu,Chowdhury Rafeed Rahman, Victor Getty, Denis Odinokov, Probhonjon Baruah, Hanaé Carrié, Avril Joy Lim, Yu Amanda Guo, Zhong Wee Poh, Ngak Leng Sim, Ahmed Abdelmoneim, Yutong Cai, Lakshmi Narayanan Lakshmanan, Danliang Ho,Saranya Thangaraju,Polly Poon, Yi Ting Lau,Anna Gan, Sarah Ng, Si-Lin Koo, Dawn Q Chong,Brenda Tay, Tira J Tan,Yoon Sim Yap, Aik Yong Chok, Matthew Chau Hsien Ng,Patrick Tan, Daniel Tan,Limsoon Wong, Pui Mun Wong,Iain Beehuat Tan, Anders Jacobsen Skanderup

Nature biomedical engineeringno. 3 (2025): 307-319

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Comprehensive Benchmarking of Methods for Mutation Calling in Circulating Tumor DNA

Hanaé Carrié,Ngak Leng Sim, Pui Mun Wong,Anna Gan,Yi Ting Lau,Polly Poon,Saranya Thangaraju,Iain BeeHuat Tan,Yoon Sim Yap,Kiran Krishnamachari, Lim Soon Wong,Anders Jacobsen Skanderup

biorxiv（2025）

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Oncogenic Non-V600 Mutations Evade the Regulatory Machinery of RAF Including the Cdc37/Hsp90 Chaperone and the 14-3-3 Scaffold

Xiaoyu Wan,Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Nazereth Chor Boon Tan, Yiying Ma, Yiting Lim, Karlina Bte Jubri, Jingyi Hu, Jimin Yuan, Ge Zhang, Quan Li,Yoon Sim Yap,Paula Lam,Mei Wang,Nai Yang Fu,Jiancheng Hu

Theranosticsno. 5 (2025): 2035-2051

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Acquired Gene Alterations in Patients Treated with Ribociclib Plus Endocrine Therapy or Endocrine Therapy Alone Using Baseline and End-of-treatment Circulating Tumor DNA Samples in the MONALEESA-2, -3, and -7 Trials

F. Andre,N. Solovieff,F. Su,A. Bardia,P. Neven,Y. S. Yap,D. Tripathy,Y. -S. Lu,D. Slamon,S. Chia,M. Joshi,A. Chakravartty,A. Lteif,T. Taran,C. L. Arteaga

ANNALS OF ONCOLOGY（2025）

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Risking Arm Lymphedema in More Than a Hundred Patients to Benefit One Patient-is It Worth It

Geok Hoon Lim,Yoon-Sim Yap, Rui Jun Lim,Lester Chee Hao Leong

Gland surgeryno. 4 (2025): 781-784

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Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Versus Combination Chemotherapy in Premenopausal Women with Clinically Aggressive Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer

Yen-Shen Lu, Eznal Izwadi Bin Mohd Mahidin,Hamdy Azim,Yesim Eralp,Yoon Sim Yap,Seock-Ah Im,Julie Rihani,Erhan Gokmen,Ahmed El Bastawisy,Nuri Karadurmus,Yueh Ni Lim,Chun Sen Lim,Le Thanh Duc,Wei-Pang Chung,K. Govind Babu,Konstantin Penkov,James Bowles,Teresa Delgar Alfaro,Jiwen Wu,Melissa Gao,Khemaies Slimane,Nagi S. El Saghir

JOURNAL OF CLINICAL ONCOLOGY（2024）

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Can Metastatic Breast Cancer Be Cured? Long-term Follow Up of Patients Diagnosed from 2001–2012

Z. Zhang, R. H. Z. Sim,S. Zhou, N. Phyu,M. Wong,F. Y. Wong,Y. S. Yap

European Journal of Cancer (2024): 113713-113713

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Supplemental Table 1 from Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7

Aleix Prat,Nadia Solovieff,Fabrice André,Joyce O'Shaughnessy,David A. Cameron,Wolfgang Janni,Gabe S. Sonke,Yoon-Sim Yap,Denise A. Yardley,Ann H. Partridge,Astrid Thuerigen,Juan Pablo Zarate,Agnes Lteif,Fei Su,Lisa A. Carey

openalex（2024）

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Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Vs Combination Chemotherapy in Premenopausal Women with Clinically Aggressive HR+/HER2− Advanced Breast Cancer

Yen-Shen Lu, Enzal Izwadi Bin Mohd Mahidin,Hamdy Azim,Yesim Eralp,Yoon Sim Yap,Seock-Ah Im,Julie Rihani,Erhan Gokmen,Ahmed El Bastawisy,Nuri Karadurmus, Yeuh Ni Lim,Chun Sen Lim,Le Thanh Duc,Wei-Pang Chung,K. Govind Babu,Konstantin Penkov,James Bowles,Teresa Delgar Alfaro,Jiwen Wu,Melissa Gao,Khemaies Slimane,Nagi S. El Saghir

Journal of Clinical Oncology（2024）

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Supplementary Figure 1 from A Phase I Study of LSZ102, an Oral Selective Estrogen Receptor Degrader, with or Without Ribociclib or Alpelisib, in Patients with Estrogen Receptor–Positive Breast Cancer

Komal Jhaveri,Dejan Juric,Yoon-Sim Yap,Sara Cresta,Rachel M. Layman,Francois P. Duhoux,Catherine Terret,Shunji Takahashi,Jens Huober,Nicole Kundamal,Qing Sheng,Alejandro Balbin, Yan Ji, Wei He,Adam Crystal,Serena De Vita,Giuseppe Curigliano

crossref（2024）

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Author Statistics

#Papers: 263

#Citation: 6960

H-Index: 40

G-Index: 80

Sociability: 7

Diversity: 3

Activity: 68

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