Yue Xu

ACADEMIC DEGREES: B.S. 2012-2016 China Pharmaceutical University, Nanjing, China (Pharmacy) M.S. 2016-2018 China Pharmaceutical University, Nanjing, China (Pharmacokinetics) Ph.D. 2018-2021 Peking University, Beijing, China (Pharmacology) EMPLOYMENT: 2023-present Postdoctoral Fellow, College of Pharmacy, The Ohio State University, OH, US 2021-2023 Postdoctoral Fellow, School of Basic Medicine Science, Peking University, Beijing, China RESEARCH INTERESTS: • Function and regulation of ATP-Binding Cassette (ABC) transporters • Preclinical pharmacology and pharmacokinetics of Urea Transporter (UT) inhibitor • Role of solute carriers (SLC) transporter protein in kidney and liver • SLC transporter regulation development and translational pharmacology PUBLICATIONS: 1. Xu Y, Zhang H, Li NN, Ma W, Wang SY, Sun JG, and Yang BX, Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters. Molecules, 2022. 27(8). 2. Xu Y, Wang SY, Ma W, Li J, Lu YY, Abulizi A, Sun JG and Yang BX, An HPLC-MS/MS Method for Pharmacokinetic Study of Y-99, a Novel Diuretic Agent Targeting Urea Transporters. J Chromatogr Sci, 2022 (Accepted) 3. Xu Y, Xiong T, Ruan TT, Sun JG and Chen GF, Research progress of P-glycoprotein induction. J China Pharm Univ, 2018,49(1):26-33 4. Li M, Zhao Y, Zhang S, Xu Y, Wang SY, Li BW, Ran JH, Li RT, and Yang BX, Thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters. Acta Pharmacologica Sinica, 2020. 41(1): p. 65-72. 5. Zhang S, Zhao Y, Wang SY, Li M, Xu Y, Ran JH, Geng XQ, He JZ, Meng J, Shao GY, Zhou H, Ge Z, Chen G, Li RT, and Yang BX, Discovery of novel diarylamides as orally active diuretics targeting urea transporters. Acta pharmaceutica Sinica B, 2021. 11(1): p. 181–202. 6. Wang SY, Xu Y, Zhao Y, Zhang S, Li M, Li XW, He JZ, Zhou H, Ge Z, Li RT, and Yang BX, N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem, 2021. 226: p. 113859. 7. He JZ, Zhang S, Qiu ZW, Li XW, Huang H, Jin W, Xu Y, Shao GY, Wang L, Meng J, Wang SY, Geng XQ, Jia YL, Li M, Yang BX, Jenny Lu HA, and Zhou H, Inhibiting focal adhesion kinase ameliorates cyst development in polycystin-1 deficient polycystic kidney disease in animal. J Am Soc Nephrol. 2021, 32(9): 2159-2174. 8. Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, and Yang BX, Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor. Acta Pharmacol Sin, 2021. 42(10):1703-1713. 9. Ma W, Xu Y, Wang SY, Li J and Yang BX, Research on accurate quantitation technique using liquid chromatography coupled with triple quadrupole mass spectrometry and experiment optimization—take a novel diuretic as an example. J Chin Pharm Sci 2022, 31(3):184-191