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    • Synthesis of Arrays Using Low Molecular Weight MPEG-Assisted Mitsunobu Reaction

    Marek Figlus,Natalie Wellaway,Anthony W. J. Cooper,Steven L. Sollis, Richard C. Hartley

    ACS combinatorial science（2011）SCI 3区

    Univ Glasgow | GSK Med Ctr

    Cited 17|Views13
    Abstract
    Triphenylphosphine tagged with a short poly(ethyleneglycol)-ω-monomethyl ether chain (light MPEG, 10−16 ethylenoxy units, MTPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate (MDEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP’s in the range of 1.4−5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase extraction (MSPE) on prepacked silica columns to give the products in good yield and high purity.
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    triphenylphosphine,Mitsunobu reaction,cLogP,solid-phase extraction
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    Chat Paper
    【要点】：该论文提出了一种使用低分子量MPEG辅助的Mitsunobu反应合成阵列的新方法，通过MTPP-G2和MDEAD制备了20个成员的酯、醚和磺酰胺库，并利用MPEG辅助的固相萃取技术实现了产物的高纯度分离。
    

    【方法】：研究利用带有短聚乙二醇链的磷酸三苯酯（MTPP-G2）和带有MPEG标签的偶氮二羧酸二乙酯（MDEAD）进行Mitsunobu反应，合成了具有不同cLogP值的有机化合物库。
    

    【实验】：实验在0.1 mmol的规模上进行，使用MPEG辅助的固相萃取（MSPE）技术对预装硅胶柱进行产物纯化，得到了高产率和高质量的产品，数据集名称未在文本中提及。
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