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Structure–activity Relationships and Key Structural Feature of Pyridyloxybenzene-Acylsulfonamides As New, Potent, and Selective Peroxisome Proliferator-Activated Receptor (PPAR) Γ Agonists

Kentaro Rikimaru,Takeshi Wakabayashi,Hidenori Abe,Taisuke Tawaraishi,Hiroshi Imoto,Jinichi Yonemori,Hideki Hirose,Katsuhito Murase,Takanori Matsuo,Mitsuharu Matsumoto,Chisako Nomura,Hiroko Tsuge,Naoto Arimura,Kazutoshi Kawakami,Junichi Sakamoto,Miyuki Funami,Clifford D. Mol,Gyorgy P. Snell,Kenneth A. Bragstad,Bi-Ching Sang,Douglas R. Dougan,Toshimasa Tanaka,Nozomi Katayama, Yoshiaki Horiguchi,Yu Momose

Bioorganic & Medicinal Chemistry（2012）

Cited 17|Views15
Key words
PPAR gamma agonists,Diabetes mellitus,SBDD,Acylsulfonamide,Isosteric replacement
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