Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. Victor Certal , Jean-Christophe Carry , Frank Halley , Angela Virone-Oddos , Fabienne Thompson , Bruno Filoche-Romme , Youssef El-Ahmad , Andreas Karlsson , Veronique Charrier , Cecile Delorme , Alexey Rak , Pierre-Yves Abecassis , Celine Amara , Loic Vincent , Helene Bonnevaux , Jean-Paul Nicolas , Magali Mathieu , Thomas Bertrand , Jean-Pierre Marquette , Nadine Michot , Tsiala Benard , Marc-Antoine Perrin , Olivier Lemaitre , Stephane Guerif , Sebastien Perron , Sylvie Monget , Florence Gruss-Leleu , Gilles Doerflinger , Houlfa Guizani , Maurice Brollo , Laurence Delbarre , Luc Benin , Patrick Richepin , Veronique Loyau , Carlos Garcia-Echeverria , Christoph Lengauer , Laurent Schio Journal of Medicinal Chemistry（2014）
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