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Structure-guided Discovery of 1,3,5 Tri-Substituted Benzenes As Potent and Selective Matriptase Inhibitors Exhibiting in Vivo Antitumor Efficacy

Rajeev Goswami,Subhendu Mukherjee,Chakshusmathi Ghadiyaram,Gerd Wohlfahrt,Ramesh K. Sistla,Jwala Nagaraj,Leena K. Satyam,Krishnaprasad Subbarao,Rajendra K. Palakurthy,Sreevalsam Gopinath,Narasimha R. Krishnamurthy,Tarja Ikonen,Anu Moilanen,Hosahalli S. Subramanya,Pekka Kallio,Murali Ramachandra

Bioorganic & Medicinal Chemistry（2014）

Cited 19|Views16
Key words
Matriptase,Amidine,Molecular docking,Crystallography,Cancer,In vivo activity
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