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Fragment-Based Discovery of 7-Azabenzimidazoles As Potent, Highly Selective, and Orally Active Cdk4/6 Inhibitors

Young Shin Cho,Hayley Angove,Christopher Brain,Christine Hiu-Tung Chen,Hong Cheng,Robert Cheng,Rajiv Chopra,Kristy Chung,Miles Congreve,Claudio Dagostin,Deborah J. Davis, Ruth Felten,John Giraldes,Steven D. Hiscock,Sunkyu Kim,Steven Kovats,Bharat Lagu,Kim Lewry,Alice Loo,Yipin Lu,Michael Luzzio,Wiesia Maniara,Rachel McMenamin,Paul N. Mortenson,Rajdeep Benning,Marc O'Reilly,David C. Rees,Junqing Shen,Troy Smith, Yaping Wang,Glyn Williams,Alison J. -A. Woolford,Wojciech Wrona,Mei Xu, Fan Yang,Steven Howard

ACS MEDICINAL CHEMISTRY LETTERS（2012）

Cited 43|Views41
Key words
CDK4/6,pRb phosphorylation,mantle cell lymphoma,fragment-based screening,structure-guided optimization
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