Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases Its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors after IV Administration
Pharmaceutical Research（2014）
关键词
drug delivery,peripheral shell cross-linking,pluronic F127,poloxamer 407,polymer nanocarriers,premature drug release,vascular disrupting agents
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