Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Bioorganic & Medicinal Chemistry Letters（2015）
关键词
HCV NS5B polymerase,Thumb pocket 1,Non-nucleoside inhibitor,Promiscuity,Lipophilicity
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