Development of a Novel Class of Potent and Selective FIXa Inhibitors
Dongfang Meng,Patrick Andre,Thomas J. Bateman,Richard Berger,Yi-Heng Chen,Kunal Desai,Sunita Dewnani,Kenneth Ellsworth, Daming Feng,Wayne M. Geissler,Liangqin Guo,Alan Hruza,Tianying Jian, Hong Li,Joe Metzger,Dann L. Parker,Paul Reichert,Edward C. Sherer,Cameron J. Smith,Lisa M. Sonatore,Richard Tschirret-Guth,Jane Wu,Jiayi Xu,Ting Zhang,Louis-Charles Campeau,Robert Orr,Marc Poirier,Jamie McCabe-Dunn, Kazuto Araki, Teruyuki Nishimura,Isao Sakurada,Tomokazu Hirabayashi,Harold B. Wood Bioorganic & Medicinal Chemistry Letters（2015）
Key words
Benzimidazole,Quninazolinone,FIXa inhibitor,TGA,Structure based drug design
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