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Discovery of MK-1421, a Potent, Selective Sstr3 Antagonist, As a Development Candidate for Type 2 Diabetes

Shrenik K. Shah,Shuwen He,Liangqin Guo,Quang Truong,Hongbo Qi,Wu Du,Zhong Lai,Jian Liu,Tianying Jian,Qingmei Hong,Peter Dobbelaar,Zhixiong Ye,Edward Sherer,Zhe Feng,Yang Yu,Frederick Wong,Koppara Samuel, Maria Madiera,Bindhu V. Karanam,Vijay B. Reddy,Stan Mitelman,Sharon X. Tong,Gary G. Chicchi,Kwei-Lan Tsao,Dorina Trusca,Yue Feng,Margaret Wu,Qing Shao,Maria E. Trujillo,George J. Eiermann,Cai Li,Michele Pachanski,Guillermo Fernandez,Donald Nelson,Patricia Bunting,Pierre Morissette,Sylvia Volksdorf,Janet Kerr,Bei B. Zhang,Andrew D. Howard,Yun-Ping Zhou,Alexander Pasternak,Ravi P. Nargund,William K. Hagmann

ACS Medicinal Chemistry Letters（2015）

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关键词
sstr3,antagonist,type 2 diabetes,tetrahydro-beta-carboline
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