Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
Alexei S. Karpov,Payman Amiri,Cornelia Bellamacina, Marie-Helene Bellance,Werner Breitenstein,Dylan Daniel,Regis Denay,Doriano Fabbro,Cesar Fernandez,Inga Galuba, Stephanie Guerro-Lagasse,Sascha Gutmann, Linda Hinh,Wolfgang Jahnke,Julia Klopp,Albert Lai,Mika K. Lindvall,Sylvia Ma,Henrik Moebitz,Sabina Pecchi,Gabriele Rummel,Kevin Shoemaker,Joerg Trappe,Charles Voliva,Sandra W. Cowan-Jacob,Andreas L. Marzinzik ACS Medicinal Chemistry Letters（2015）
关键词
PAK1,p21 activated kinase,allosteric inhibitor,dibenzodiazepine,tool compound
AI 理解论文
溯源树
样例
