Design of Pyridopyrazine-1,6-dione Γ-Secretase Modulators That Align Potency, MDR Efflux Ratio, and Metabolic Stability
Martin Pettersson,Douglas S. Johnson,John M. Humphrey,Todd W. Butler,Christopher W. Am Ende,Benjamin A. Fish,Michael E. Green,Gregory W. Kauffman,Patrick B. Mullins,Christopher J. O'Donnell,Antonia F. Stepan,Cory M. Stiff,Chakrapani Subramanyam,Tuan P. Tran, Beth Cooper Vetelino,Eddie Yang,Longfei Xie,Kelly R. Bales,Leslie R. Pustilnik,Stefanus J. Steyn,Kathleen M. Wood,Patrick R. Verhoest ACS medicinal chemistry letters（2015）
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Alzheimer's disease,gamma secretase modulators,fluorine,lipophilic metabolism efficiency,LipMetE
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