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Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing Γ-Secretase-aβn Interactions

Maria Szaruga,Bogdan Munteanu,Sam Lismont,Sarah Veugelen,Katrien Horré,Marc Mercken,Takaomi C. Saido,Natalie S. Ryan,Tatjana De Vos,Savvas N. Savvides,Rodrigo Gallardo,Joost Schymkowitz,Frederic Rousseau,Nick C. Fox,Carsten Hopf,Bart De Strooper,Lucía Chávez-Gutiérrez

Cell（2021）

Cited 228|Views45
Key words
Alzheimer’s disease,γ-secretase,presenilin,amyloid precursor protein,amyloid beta,protein thermosability,enzyme thermoactivity
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