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Inflammation and Immunogenicity Limit the Utility of the Rabbit As a Nonclinical Species for Ocular Biologic Therapeutics

Christina L. Zuch de Zafra,Vito G. Sasseville, Steven Matsumoto,Christian Freichel,Mark Milton,Timothy K. MacLachlan,Cindy Farman,Iona Raymond,Swati Gupta, Ronald Newton,Elke-Astrid Atzpodien,Evan A. Thackaberry

Regulatory Toxicology and Pharmacology（2017）

引用 30|浏览26
关键词
Biologic,Ocular,Ophthalmic,Rabbit,Anti-drug antibody,Inflammation,3Rs
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