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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Natalia Martinez-Soria,Lynsey McKenzie,Julia Draper,Anetta Ptasinska,Hasan Issa,Sandeep Potluri,Helen J. Blair,Anna Pickin,Asmida Isa,Paulynn Suyin Chin,Ricky Tirtakusuma,Daniel Coleman,Sirintra Nakjang,Salam Assi,Victoria Forster,Mojgan Reza, Ed Law,Philip Berry,Dorothee Mueller,Alex Elder,Simon N. Bomken,Deepali Pal,James M. Allan,Gareth J. Veal,Peter N. Cockerill,Christian Wichmann,Josef Vormoor,Georges Lacaud,Constanze Bonifer,Olaf Heidenreich

Cancer Cell（2018）

Cited 99|Views57
Key words
RNAi screen,fusion gene,cell-cycle control,CDK6 inhibition,RUNX1/ETO,CCND2,acute myeloid leukemia,palbociclib,KIT mutation,imatinib
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