Quantification of in Vivo Site-Specific Asp Isomerization and Asn Deamidation of Mabs in Animal Serum Using IP-LC-MS.

John T. Mehl,Bogdan G. Sleczka,Eugene F. Ciccimaro,Alexander T. Kozhich, Deb G. Gilbertson,Ragini Vuppugalla,Christine S. Huang,Brenda Stevens,Jingjie Mo,Ekaterina G. Deyanova,Yun Wang,Richard Y. C. Huang,Guodong Chen,Timothy V. Olah

Bioanalysis（2016）

引用 21|浏览33

关键词

asparagine deamidation,aspartic acid isomerization,CDR,immunoprecipitation,in vivo deamidation,in vivo isomerization,LC-MS,mAb therapeutic,monoclonal antibody,MS,therapeutic protein quantification

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要