Brain Penetrant Liver X Receptor (lxr) Modulators Based on A 2,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole Core
Colin M. Tice,Paul B. Noto,Kristi Yi Fan,Wei Zhao,Stephen D. Lotesta,Chengguo Dong,Andrew P. Marcus,Ya-Jun Zheng,Guozhou Chen,Zhongren Wu,Rebecca Van Orden,Jing Zhou,Yuri Bukhtiyarov,Yi Zhao,Kerri Lipinski,Lamont Howard,Joan Guo,Geeta Kandpal,Shi Meng,Andrew Hardy,Paula Krosky,Richard E. Gregg,Katerina Leftheris,Brian M. McKeever,Suresh B. Singh,Deepak Lala,Gerard M. McGeehan,Linghang Zhuang,David A. Claremon BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2016）
关键词
LXR,Structure-based drug design,Alzheimer's disease,Brain
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