Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)
Organic Process Research & Development（2018）
Key words
diastereoselective,fluorination,cuprate,conjugate addition,sulfoxide,elimination,gamma-lactam
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