Framework Mutations of the 10-1074 Bnab Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
Journal of Pharmaceutical Sciences（2019）
关键词
analytical biochemistry,antibody(s),biopharmaceutical characterization,developability,fluorescence spectroscopy,high throughput technology(s),HIV/AIDS,pharmacokinetics,physical stability,protein aggregation,protein folding,protein structure,stability,stabilization
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