Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial Gerard J. Criner , Antoine Delage , Kirk Voelker , D. Kyle Hogarth , Adnan Majid , Michael Zgoda , Donald R. Lazarus , Roberto Casal , Sadia B. Benzaquen , Robert C. Holladay , Adam Wellikoff , Karel Calero , Mark J. Rumbak , Paul R. Branca , Muhanned Abu-Hijleh , Jorge M. Mallea , Ravi Kalhan , Ashutosh Sachdeva , C. Matthew Kinsey , Carla R. Lamb , Michael F. Reed , Wissam B. Abouzgheib , Phillip Kaplan , Gregory X. Marrujo , David W. Johnstone , Mario G. Gasparri , Arturo A. Meade , Christopher A. Hergott , Chakravarthy Reddy , Richard A. Mularski , Amy Hajari Case , Samir S. Makani , Ray W. Shepherd , Benson Chen , Gregory E. Holt , Simon Martel , Douglas Wood , Robert Wise , Felix Herth , Christopher Cooper , Paul Jones , Atul Mehta , Steve Springmeyer , Daniel Sterman , Greg Sessler , Nawzer Mehta , Douglas Sheffield , Michelle Tobin , Susan Anton , Tom Matthews , Gerald Guidry , Eriika Etshokin , Lauri DeVore , Jacki Campbell , Victoria Simonnet , Amanda Whitson , Bill Sirokman , David Himes , Andy Mugglin , Caitlin Rothermel , John Beamis , Greg Campbell , Frank Detterbeck , Barry Make , Jonathon Truwit , Matthew Brenner , Richard Helmers , Eric Vallieres , Roger Yusen , Robert Kruklitis , Daniel Nader AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE（2019）
Key words
chronic obstructive pulmonary disease, FEV, quality of life
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