Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation

Matthew T. Trivett, James D. Burke,Claire Deleage,Lori Coren,Brenna J. Hill,Sumiti Jain,Eugene Barsov,Matthew W. Breed,Joshua A. Kramer,Gregory Q. Del Prete,Jeffrey D. Lifson,Adrienne E. Swanstrom,David E. Ott

Journal of Virology（2019）

Cited 9|Views57

Key words

adoptive cell therapy,adoptive cell transfer,CCL25,CCR9,immunology,infused cell persistence,SIV,small intestine,T cell homing,T cell immunotherapeutics

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