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Structure Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of Cyclic P1 Linker Moieties with Improved Oral Bioavailability

Charles G. Clark,Karen A. Rossi,James R. Corte,Tianan Fang,Joanne M. Smallheer,Indawati De Lucca,David S. Nirschl,Michael J. Orwat,Donald J. P. Pinto,Zilun Hu,Yufeng Wang,Wu Yang,Yoon Jeon,William R. Ewing,Joseph E. Myers,Steven Sheriff,Zhen Lou,Jeffrey M. Bozarth,Yiming Wu,Alan Rendina,Timothy Harper,Joanna Zheng,Baomin Xin,Qian Xiang,Joseph M. Luettgen,Dietmar A. Seiffert,Ruth R. Wexler,Patrick Y. S. Lam

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2019）

Cited 11|Views60
Key words
Factor XIa inhibitors,FXIa,Activated partial thromboplastin time,aPTT,Thrombosis,Anticoagulant,Bioavailability
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