Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt—Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy David Marcoux , James J. -W. Duan , Qing Shi , Robert J. Cherney , Anurag S. Srivastava , Lyndon Cornelius , Douglas G. Batt , Qingjie Liu , Myra Beaudoin-Bertrand , Carolyn A. Weigelt , Purnima Khandelwal , Sureshbabu Vishwakrishnan , Kumaravel Selvakumar , Ananta Karmakar , Arun Kumar Gupta , Mushkin Basha , Sridharan Ramlingam , Naveen Manjunath , Sridhar Vanteru , Sukhen Karmakar , Nageswara Maddala , Muthalagu Vetrichelvan , Anuradha Gupta , Richard A. Rainpulla , Arvind Mathur , Shiuhang Yip , Peng Li , Dauh-Rurng Wu , Javed Khan , Max Ruzanov , John S. Sack , Jinhong Wang , Melissa Yarde , Mary Ellen Cvijic , Sha Li , David J. Shuster , Virna Borowski , Jenny H. Xie , Kim W. McIntyre , Mary T. Obermeier , Aberra Fura , Kevin Stefanski , Georgia Cornelius , John Hynes , Joseph A. Tino , John E. Macor , Luisa Salter-Cid , Rex Denton , Qihong Zhao , Percy H. Carter , T. G. Murali Dhare Journal of Medicinal Chemistry（2019）
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