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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression in Vivo.

Longchuan Bai,Haibin Zhou,Renqi Xu,Yujun Zhao,Krishnapriya Chinnaswamy,Donna McEachern,Jianyong Chen,Chao-Yie Yang,Zhaomin Liu,Mi Wang, Liu,Hui Jiang,Bo Wen,Praveen Kumar,Jennifer L. Meagher,Duxin Sun,Jeanne A. Stuckey,Shaomeng Wang

Cancer Cell（2019）

引用 420|浏览127
关键词
STAT3,SH2 domain,PROTAC,degrader,selectivity,transcriptional factor,undruggable,leukemia,lymphoma,c-Myc
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