Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
James R. Corte,Donald J. P. Pinto,Tianan Fang,Honey Osuna,Wu Yang,Yufeng Wang,Amy Lai,Charles G. Clark,Jung-Hui Sun,Richard Rampulla,Arvind Mathur,Mahammed Kaspady, Premsai Rai Neithnadka, Yi-Xin Cindy Li,Karen A. Rossi,Joseph E. Myers,Steven Sheriff,Zhen Lou,Timothy W. Harper,Christine Huang,Joanna J. Zheng,Jeffrey M. Bozarth,Yiming Wu,Pancras C. Wong,Earl J. Crain,Dietmar A. Seiffert,Joseph M. Luettgen,Patrick Y. S. Lam,Ruth R. Wexler,William R. Ewing Journal of Medicinal Chemistry（2019）
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Factor XI Antisense Oligonucleotide
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