CFTR Transmembrane Segments Are Impaired in Their Conformational Adaptability by a Pathogenic Loop Mutation and Dynamically Stabilized by Lumacaftor
JOURNAL OF BIOLOGICAL CHEMISTRY（2020）
Key words
cystic fibrosis transmembrane conductance regulator (CFTR),cystic fibrosis,single-molecule biophysics,membrane protein,protein misfolding,helical packing,lumacaftor,pharmacological corrector,single-molecule F?rster resonance energy transfer (FRET)
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