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Structure-based Optimisation of Orally Active & Reversible MetAP-2 Inhibitors Maintaining a Tight 'molecular Budget'.

David J. Hirst,Martin Brandt,Gordon Bruton,Erica Christodoulou,Leanne Cutler,Nigel Deeks, Jonathan D. Goodacre, Torquil Jack,Matthew Lindon,Afjal Miah, Kevin Page,Nigel Parr,Lena Shukla, Martin Sims,Pamela Thomas,James Thorpe,Duncan S. Holmes

Bioorganic & Medicinal Chemistry Letters（2020）

Cited 6|Views91
Key words
Methionine aminopeptidase-2,MetAP-2,Molecular budget,Structure-based drug design,Indole carboxamide
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