Co-crystal Structures of HIV TAR RNA Bound to Lab-Evolved Proteins Show Key Roles for Arginine Relevant to the Design of Cyclic Peptide TAR Inhibitors
Journal of Biological Chemistry（2020）
Key words
HIV TAR,HIV Tat,RNA-protein interactions,cyclic peptide inhibitor,arginine-rich domain,drug discovery,isothermal titration calorimetry,surface plasmon resonance,peptide chemical synthesis,X-ray crystallography,human immunodeficiency virus (HIV),RNA-binding protein,RNA structure,RNA-protein interaction,cyclic peptide,surface plasmon resonance (SPR),isothermal titration calorimetry (ITC)
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