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    • New Players on the Pirna Field

    Maria Ninova,Katalin Fejes Tóth

    Nature structural & molecular biology（2020）

    California Institute of Technology

    Cited 4|Views4
    Abstract
    The nuclear piRNA pathway safeguards genome integrity in the germline by silencing transposable elements. Three recent studies have identified new players in the mammalian pathway. Two of these, TEX15 and SPOCD1, might provide a link between piRNA-guided complexes that recognize genomic targets and the molecular machinery that induces DNA methylation and transcriptional repression during mouse spermatogenesis.
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    Key words
    DNA methylation,Gene silencing,Piwi RNAs,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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