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125 I粒子食管支架在食管癌中的应用

Women's Health Research(2020)

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Abstract
目的:探讨125I粒子食管支架在治疗食管癌中的应用价值.方法:选取2017年3月至2019年2月在本院接受治疗的食管癌患者进行随机对照研究,去除拒绝、退出、失访等因素后最终纳入52例患者进行统计,研究组27例,对照组25例.其中研究组接受125 I粒子食管支架置入,对照组接受12Gy单剂量短距离放疗.每30d通过问卷调查或电话随访,直至患者死亡.观察患者生存时间、吞咽困难改善程度及并发症发生情况.结果:1)两组的中位生存时间相当(研究组vs.对照组=167d vs.163d),两者差异无显著性(P=0.887).2)两组接受治疗后吞咽困难指数较治疗前均有明显改善(P=0.000).在接受治疗的前60d,研究组吞咽困难改善程度优于对照组(P=0.000).3)研究组严重胸痛的发生率(22.22%)高于对照组(0.00%)(P<0.05),但瘘管形成、吸入性肺炎、消化道出血、吞咽困难复发的发生率两组比较差异均不具备统计学意义(P>0.05).结论:125 I粒子食管支架可以更快的改善患者的吞咽困难程度,提高患者的生活质量,同时其中位生存时间与短距离放疗相当,且不增加并发症发生率.
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