人类免疫遗传基因在慢性肾小球肾炎病人中的表达
GUANGZHOU MEDICAL JOURNAL（1999）
Abstract
对219例慢性肾小球肾炎尿毒症(CGN)病人和406例健康人群进行HLA免疫基因的频率、单倍型频率分析和疾病关联研究.结果:在疾病组中HLA-B13、B35、B55、DR7、DR10、DR12、DQ7基因频率和A11-B60、A11-DR10、A11-DR12、A11-DQ7、A24-DR14、DR10-B60、DR10-DQ7、DR12-DQ7单倍型频率显著升高,B46-DQ9显著降低,RR均＞3.84,P均＜0.05.提示HLA免疫基因与易感GN之间强关联,是最终导致肾功能衰竭的风险因素,其中B55、DR10、DQ7为国内外相关研究中首次报道,可能是疾病人群特有的地区性风险因子.
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