糖尿病肾病足细胞损伤机制及中药 对其保护作用的研究进展
Youjiang Medical Journal（2019）
Abstract
随着我国糖尿病( DM)发病率逐年攀升,预计到2025年,我国糖尿病增长率将接近发达国家2 倍.糖尿病肾病( DN)继发于DM,以蛋白尿为突出表现,最终发展至终末期肾病( ESRD ). 足细胞( podo-cyte)是肾小球基底膜( GBM)外侧的高分化细胞,有Nephrin、Podocin等多种裂隙膜蛋白构成肾小球滤过的屏障,膜蛋白的损伤或缺失可引起大量蛋白尿.近年研究发现,足细胞损伤是DN发生、发展的关键环节之一.
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