白细胞介素-10、干扰素-γ在口腔扁平苔藓上皮下结缔组织中的表达及临床意义
Guangxi Medical Journal（2015）
Abstract
目的：探讨白细胞介素-10（IL-10）、干扰素-γ（IFN-γ）在口腔扁平苔藓（OLP）患者病灶皮下结缔组织中的表达及临床意义。方法应用荧光实时定量PCR法（ RT-PCR）检测20例OLP患者病灶皮下结缔组织和15例健康对照组口腔黏膜组织的IFN-γ、IL-10 mRNA水平。结果 OLP组病灶皮下结缔组织IFN-γmRNA水平明显高于对照组口腔黏膜组织（P＜0．05），IL-10 mRNA水平明显低于对照组口腔黏膜组织（P＜0．05）。结论 IFN-γ与IL-10两者协同参与OLP的病理过程，在OLP病损形成中起到一定作用。
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