应用脉搏指示连续心排血量监测技术评价左西孟旦注射液联合参附注射液对重症射血分数降低型心力衰竭住院患者血流动力学的影响

Gang He,Hongxu Liu,Qi Zhou,Wei Tian,Xiaolei Lai,Tong Tong,Ying Zhou

China Medicine（2020）

Cited 16|Views23

Abstract

目的应用脉搏指示连续心排血量(PICCO)监测技术观察左西孟旦注射液联合参附注射液对重症射血分数降低型心力衰竭(HFrEF)患者血流动力学的影响.方法选取2016年9月至2018年11月在首都医科大学附属北京中医医院心脏重症监护病房住院的HFrEF患者32例,应用PICCO监测技术观察患者采用左西孟旦注射液联合参附注射液治疗0、2、24 h的血流动力学指标,包括有创动脉压[收缩压、舒张压和有创测量平均压(IMBP)]、心率、心排指数、每搏输出量指数(SVI)、外周血管阻力指数(SVRI)、胸腔血容量指数(ITBI).结果给药24 h后患者收缩压、舒张压、IMBP均明显高于给药0 h[(115±14)mmHg(1 mmHg=0.133 kPa)比(93±11)mmHg、(72±8)mmHg比(45±5)mmHg、(86±11)mmHg比(61±8)mmHg],差异均有统计学意义(均P<0.05).给药2 h后患者心率明显高于给药0 h[(121±14)次/min比(115±13)次/min],给药24 h后心率[(109±13)次/min]明显低于给药0 h,差异均有统计学意义(均P<0.05).给药2、24 h后患者心排指数、SVI均明显高于给药0 h[(2.6±0.9)、(3.7±1.4)L/(min·m2)比(2.1±0.6)L/(min·m2);(24.8±3.2)、(37.9±3.8)ml/m2比(20.7±2.7)ml/m2],SVRI均明显低于给药0 h[(2669±169)、(2826±174)dyn·sec·m2/cm5比(3820±213)dyn·sec·m2/cm5](均P<0.05).给药0、2、24 h患者ITBI比较,差异无统计学意义(P>0.05).结论左西孟旦注射液联合参附注射液可以提高HFrEF患者血压、心肌收缩力,增加患者的心排血量,并能减低患者的心脏后负荷,还可以在用药初始有效预防低血压的发生,经PICCO监测技术,两药联合应用可以有效实现血流动力学疗效的叠加及不良反应的降低,可以作为一种有效的临床联合用药方案应用于HFrEF患者的治疗.

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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