视黄醇结合蛋白4及超敏C反应蛋白在2型糖尿病视网膜病变中的作用
Shandong Medical Journal（2015）
Abstract
目的：探讨视黄醇结合蛋白4（RBP4）、超敏C反应蛋白（hs-CRP）水平与2型糖尿病视网膜病变（DR）的关系。方法选取119例2型糖尿病患者，根据是否合并DR及病变的严重程度分为3组，其中无视网膜病变组（ NDR组）56例、非增殖期糖尿病视网膜病变组（ SDR组）31例、增殖期糖尿病视网膜病变组（ PDR组）32例，选择58例健康体检者作为对照组（ NDM组）。所有受试者均测定RBP4、hs-CRP，并测定OCTT及胰岛素释放试验、糖化血红蛋白（HbA1c）及生化指标。结果 NDR组、SDR组、PDR组血清RBP4、hs-CRP水平显著高于NDM组（P＜0．01）。血清RBP4与hs-CRP浓度呈正相关（r＝0．638，P＜0．01）。 Logisitic回归分析示血清RBP4、hs-CRP是DR的危险因素。结论血清RBP4、hs-CRP浓度在DR患者中显著升高，两者水平变化与DR的发生、发展密切相关。
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