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    • 卵巢子宫内膜异症不孕患者异位内膜组织中FMO3、DMBT1的表达变化及其意义

    王秋阳,林伟,王福玲,王雅琦,许伟伟

    wf（2017）

    Cited 3|Views32
    Abstract
    目的：观察卵巢子宫内膜异位症（EMs）不孕患者异位内膜组织中的含黄素单氧化酶3（FMO3，在输卵管上皮组织高表达）、脑恶性肿瘤缺失基因（DMBT1，在子宫内膜组织高表达）mRNA 及蛋白，并探讨其意义。方法将卵巢 EMs 不孕患者的异位内膜组织40例份作为观察组，选取卵巢 EMs 已育患者的异位内膜组织50例份作为对照组，以正常卵巢组织35例份作为正常组。采用 real-time PCR 法检测三组 FMO3、DMBT1 mRNA，采用 Western blotting 法检测 FMO3、DMBT1蛋白。结果观察组 FMO3 mRNA 及蛋白相对表达量高于对照组和正常组（P 均＜0．05）；观察组、对照组 DMBT1 mRNA 及蛋白相对表达量高于正常组（P 均＜0．05）。结论卵巢 EMs 不孕患者异位内膜组织中 FMO3呈高表达，异位内膜组织来源可能为输卵管；输卵管组织来源的异位内膜组织可能与卵巢EMs 患者不孕有关。
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