基质金属蛋白酶-2基因1306C/T多态性与前列腺癌易感性关联的Meta分析
Acta Academiae Medicinae Jiangxi（2019）
Abstract
目的 系统评价基质金属蛋白酶-2基因(matrix metalloproteinase 2,MMP2)基因rs243865单核苷酸多态性与前列腺癌易感性的关联.方法 检索PubMed、Embase、Medline以及中国知网、万方数据库和中国生物医学文献数据库,查找有关MMP2基因rs243865位点多态性与癌症易感性关联的病例对照研究,检索时限为建库至2018年4月1日.由2名研究者筛选文献、提取数据后,使用纽卡斯尔-渥太华量表(Newcastle-Ottawa scale,NOS)进行文献的质量评价.采用Stata 12.0软件进行Meta分析,通过敏感性分析考察结果 的稳定性、亚组分析探讨异质性来源、Begg秩相关法评价发表偏倚.结果共纳入6篇文献,合计3909例研究对象,其中前列腺癌患者1921例,健康对照1988例.Meta分析结果显示,等位基因模型T vs.C(OR=1.105,95％CI:0.994～1.227)、隐性基因模型TT vs.CT+CC(OR=1.014,95％CI:0.781～1.315)和纯合子模型TT vs.CC(OR=1.086,95％CI:0.832～1.418)中,癌症易感性差异无统计学意义;显性基因模型TT+CT vs.CC(OR=1.157,95％CI:1.017～1.317)和杂合子模型TC vs.CC(OR=1.498,95％CI:1.078～2.080)中,癌症易感性差异有统计学意义.结论 MMP2基因rs243865多态性与前列腺癌易感性相关,其中C等位基因可能是保护因素,而T等位基因可能是前列腺癌的易感因素,TC基因型可能为前列腺癌患者的风险基因型.
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