DWI阴性的急性缺血性脑卒中患者rt-PA静脉溶栓的 临床研究
Neural Injury and Functional Reconstruction（2018）
Abstract
目的:观察发病24 h内头部弥散加权成像(DWI)阴性的急性缺血性脑卒中患者rt-PA静脉溶栓的临床疗效及安全性.方法:回顾性分析行rt-PA静脉溶栓的急性缺血性脑卒中患者78例临床资料,根据患者入院后头部DWI检查结果,将患者分为DWI阳性组69例和DWI阴性组9例,分析比较2组患者的基本资料、入院至溶栓时间(DNT)、症状性颅内出血、3个月预后良好(MRS<2分)比例、死亡率、发病至DWI扫描时间、后循环梗死比例等指标.结果:2组患者基本资料差异无统计学意义(P>0.05);2组低密度脂蛋白(LDL)、DNT、发病至扫描时间、后循环脑梗死比例差异有统计学意义(P<0.05);2组症状性颅内出血发生率低和死亡率差异无统计学意义(P>0.05);DWI阴性组90 d MRS<2分的比例较高(P<0.05).结论:与DWI阳性患者相比,DWI阴性的急性缺血性脑卒中患者rt-PA静脉溶栓后临床疗效更好,安全性相当.
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