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立体定向放射治疗联合吉西他滨治疗局部晚期胰腺癌疗效分析

Cancer Research and Clinic(2012)

Cited 5|Views18
Abstract
目的 评价立体定向放射治疗联合吉西他滨与吉西他滨单药治疗局部晚期胰腺癌的疗效.方法 对治疗组56例胰腺癌患者行立体定向放射治疗(总剂量4000~4500 cGy,10次分割)联合盐酸吉西他滨单药化疗(500 mg/m2第1、8天).对照组50例仅行盐酸吉西他滨单药化疗(500 mg/m2第1、8、15天).结果 治疗结束后2个月CT复查,治疗组及对照组缓解率分别为82%(46/56)、36%(18/50)(P<0.05),疼痛控制率分别为67%(33/49)、15%(7/47)(P<0.05).治疗组中位无进展生存期为14.0个月,较对照组的7.5个月明显延长(P<0.05).治疗组与对照组中位生存期分别为15.8、13.2个月(P>0.05).结论 立体定向放射治疗联合吉西他滨治疗局部晚期胰腺癌较单药化疗近期疾病控制率较高,能延长患者无病生存期,显著提高患者的生存质量.
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