ESR1基因突变与乳腺癌内分泌治疗耐药的相关性
Chinese Journal of Breast Disease(Electronic Version)(2017)
Abstract
乳腺癌是目前全世界最常见的女性恶性肿瘤.ER在乳腺癌的内分泌治疗占有中心地位,但内分泌治疗过程中获得性耐药逐渐成为突出的问题.近年来,研究者利用二代测序技术检测出了数量可观的ESR1基因突变,并对这些突变基因的功能进行了初步探索,提出ESR1基因突变对乳腺癌进展及内分泌治疗耐药的产生可能发挥重要作用;同时,新的基因突变检测平台也在不断开发.这些研究成果为解决乳腺癌内分泌治疗耐药问题提供了新的思路,并为构建耐药基因突变监测系统提供了可能.
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