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    • 关于"中国女性心血管疾病预防专家共识"中绝经相关激素治疗对心血管疾病影响的反馈

    杨欣,穆玉兰,郁琦

    Chinese Journal of Internal Medicine（2018）

    Cited 6|Views10
    Abstract
    《中华内科杂志》编辑部: 由于女性心血管疾病与绝经关系密切,我们学组对相关指导性文件一直很重视.贵刊2017年第6期472-476页发表了《中国女性心血管疾病预防专家共识》,拜读之后,深感获益匪浅;但该共识在第一部分中对于绝经和绝经激素治疗与女性心血管疾病(cardiovascular disease,CVD)的关系有这样的描述":绝经是女性独有的CVD危险因素.心脏与雌/孕激素替代治疗研究(hear't and estrogen/progestin replacement study,HERS)提示,绝经期女性使用雌激素增加血栓栓塞的风险.雌激素治疗1年内发生静脉血栓的风险增加.妇女健康行动(women's health initiative,WHI)为健康女性绝经期后冠心病一级预防的大规模随机对照研究,结果显示雌激素替代治疗增加CVD风险,使乳腺癌发病率增加.英国研究显示,口服雌激素增加卒中风险,而使用雌二醇透皮贴不增加卒中风险."文中提到的WHI和HERS研究目前已有新的评价,关于绝经相关激素治疗(menopause related hormone therapy,MHT)也有新的研究结果问世,本着深入探讨,共同发展的原则,特将现有的证据加以总结,供编辑部、作者和读者参考.
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