封闭式负压引流对人压力性溃疡创面S100A9蛋白表达的影响
Lingnan Journal of Emergency Medicine（2015）
Abstract
目的：研究封闭式负压引流技术对人压力性溃疡S100A9蛋白的表达影响以探讨其促进创面愈合的可能机制。方法：将28例Ⅲ－Ⅳ期及不可分期的压力性溃疡患者随机分成实验组（14例）和对照组（14例），实验组患者创面应用封闭式负压引流治疗，对照组患者创面应用常规敷料换药治疗，两组患者分别于治疗前1 d，治疗后4 d、7 d、14 d取创面创缘全层皮肤组织，应用免疫组织化学染色法检测标本组织中的S100A9蛋白的表达情况。结果：随着治疗时间延长，实验组和对照组S100A9蛋白阳性表达细胞数开始增加，都表达于中性粒细胞及单核巨噬细胞的细胞质中，治疗第14天，实验组肉芽组织中表达S100A9蛋白的炎症细胞数高于对照组（75．93±1．88 vs 55．13±1．03， P＜0．01）。结论：封闭式负压引流疗法较普通换药更能够上调创缘组织中与创面愈合密切相关的S100A9蛋白表达来促进创面愈合。
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Key words
vacuum assisted closure,pressure ulcer,S100A9 protein
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