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人心房利钠肽对小鼠机械通气肺损伤炎症反应的影响

次仁桑珠, 郇霞

Clinical Medicine(2014)

Cited 2|Views3
Abstract
目的:探讨人心房利钠肽(hANP)对小鼠机械通气所致肺损伤(VILI)时炎症反应的影响。方法将30只雄性 C57 B∕6小鼠随机分为空白对照组(C 组)、机械通气肺损伤组(MV 组)和人心房利钠肽组(MV + hANP 组)。MV +hANP 组腹腔注射 hANP 2μg∕ kg 后行机械通气,通气3 h 后取材,处死小鼠。采用流式多重蛋白定量技术(CBA)测定小鼠血浆中炎性细胞因子浓度;分离左肺,计算肺组织湿干比值。结果与 C 组相比,MV 组、HV + hANP 组血浆中巨噬细胞炎性蛋白_1[(461?7±91?97)、(348?0±74?40)pg∕ ml]、肿瘤坏死因子_α[(59?10±7?94)、(48?40±8?34)pg∕ ml]和白细胞介素_6[(701?7±88?13)、(607?9±61?67)pg∕ ml]含量明显上升(p <0?05),肺组织 W∕ D 值[(4?74±0?84)、(4?61±0?721)]明显升高(p <0?05);与 MV 组相比,HV + hANP 组血浆中巨噬细胞炎性蛋白_1、肿瘤坏死因子_α、白细胞介素_6明显降低(p <0?05),肺组织 W∕ D 降低(p <0?05)。结论人心房钠尿肽能够减轻机械通气所导致的炎症反应,从而减轻肺损伤。
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